13:00 h Registration opens at Venue
Palacio de Congresos Conde Ansurez
16:30 h Welcome address by Chair Jan Parys (Belgium), ECS president Marc Moreau (France) and Local Organizer Carlos Villalobos (Spain).
17:00 h Opening Conference
Prof. Javier García-Sancho (Spain) Introduced by Carlos Villalobos (Spain)
Measuring Ca2+ inside intracellular organelles
18:30 h Walking Tour of Historic Valladolid (60-90 min)
20:00 h Welcome Reception at “Palacio de Santa Cruz”
08:30 h Ca2+ and neurological disease: in search for novel targets.
Chair, Carlos Gutierrez-Merino (Spain)
Antonio G. García (Spain).
Altered Ca2+ and exocytotic fusion pore in neurodegenerative diseases
Jacek Kuznicki (Poland).
Dysregulation of Ca2+ signaling in neurodegenerative diseases.
Ana Mata (Spain)
Functional modulation of plasma membrane Ca2+ pumps by molecular markers of Alzheimer´s disease
Elizabeth Yates (UK) Selected oral Communication
Lysosomes, Ca2+ and LRRK2: a toxic relationship in Parkinson disease?
Matej Hotka (Austria) Selected oral Communication
Investigating the link between mitochondria, Ca2+ and epileptiform activity.
10:30 h Coffee break #1
11:00 h Late-breaking research symposium.
Chair, Jan Parys (Belgium)
Andreas Guse (Germany)
2'-Deoxy-ADPR: a novel second messenger activating TRPM2
Carlos Enrich (Spain)
Annexin A6 interacts with TBC1D15 to regulate Rab7 activity and cholesterol homeostasis
Israel Sekler (Israel)
The optometabolic strategy; light-dependent control of mitochondria metabolism and Ca2+ signaling
12:00 h Flash symposium.
Chair, Sandip Patel (UK)
10-15 quick, 4-5 min poster presentations TBA
13:00 h Lunch #1
14:00 h Poster Session #1
15:30 h Good and bad sides of Ca2+ signaling in human disease
Chair Natalya Prevarskaya (France)
Victoria Bolotina (USA)
Ca2+ signaling path to autophagic dysfunction and Parkinson's disease
Barbara Ehrlich (USA)
Cancer treatment alters Ca2+ signaling and causes neuropathic pain, but the changes can be prevented
Joost Hoenderop (The Netherlands)
Renal calcium handling and the anti-aging hormone klotho
Katja Rietdorf (UK) Selected oral Communication
How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility.
Miguel Burgos (Spain) Selected oral Communication
E152K STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis.
17:30 h Coffee break
18:00 h Targeting calmodulin receptor interaction in cancer chemotherapy
Chair, David Sacks (USA)
G. Prem Veer Reddy (USA)
The functional interaction of calmodulin with androgen receptors in prostate cancer
James Ames (USA)
Structural basis for Ca2+-induced activation and dimerization of ERα by calmodulin
Antonio Villalobo (Spain)
Regulation of the EGFR by calmodulin: mechanism and therapeutic implications
Marie Potier-Cartereau (France) Selected oral Communication
Lipid raft KCa/Ca2+ channel complexes: novel targets to reduce tumor development by lipids
Alexia Vautrin (France) Selected oral Communication
Type 3 Inositol (1,4,5)-trisphosphate receptor: a migratory modulator with a unique calcium signature in breast cancer cells
21:00 Speakers dinner at local tapas restaurant
08:30 h Ca2+ remodeling in cancer
Chair, Gary S. Bird (USA)
Juan A. Rosado (Spain)
Ca2+ entry abnormalities in leukemia and breast cancer cells.
Geert Bultynck (Belgium)
Understanding and targeting the ER functions of Bcl-2 in cancer
Carlos Villalobos (Spain)
Calcium remodeling in colon cancer
John Bassett (Australia) Selected oral Communication
Assessment of cytosolic free calcium levels in GCaMP6m expressing MDA-MB-231 breast cancer cells undergoing cell death using time-lapse high-content imaging.
Maggie L. Kalev-Zylinska (New Zealand) Selected oral Communication
Glutamate-mediated calcium entry in megakaryocytic cells: evidence for a hijacking effect to support leukaemia growth.
10:30 h Coffee break #2
11:00 h ER-mitochondrial Ca2+ signaling in disease & therapy
Chair, Geert Bultynck (Belgium)
Paolo Pinton (Italy)
Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of tumor cell fate
Darren Boehning (USA)
Novel Ca2+ signaling pathways in T cells: implications for autoimmunity and cancer
Jennifer Rieusset (France)
Role of endoplasmic reticulum-mitochondria coupling in hepatic metabolic diseases
Benjamin Delprat (France) Selected oral Communication
ER-mitochondria crosstalk is regulated by WFS1/WIP1 interaction and is impaired in Wolfram syndrome
Tomás Gutiérrez (Canada) Selected oral Communication
Regulation of ER-mitochondria contacts and SERCA activity by the ER chaperones CNX and TMX1
13:00 h Lunch #2
14:00 h Poster Session #2
15:30 h Tribute to Prof. Michael Sanderson and Prof. Roger Tsien
Chair Martin D. Bootman (UK)
Juan Llopis (Spain), Katja Rietdorf (UK), and Luc Leybaert (Belgium).
Video message from Tullio Pozzan (Italy)
16:00 h Plenary Conference
Prof. Erwin Neher (Germany). Nobel prize 1991. Introduced by Roland Pochet (Belgium)
Dynamics of [Ca2+] changes during bursts of activity at the 'Calyx of Held´synapse
17:30 h Visit to National Museum of Sculpture
08:30 h Structures of calcium ion channels
Chair, Mitsu Ikura (Canada) and Walter Chazin (USA)
Peter B. Stathopulos (Canada)
Structural insights into mitochondrial Ca2+ regulation
Irina Serysheva (USA)
Structure and function of the IP3R1 Ca2+ channel: insights from cryo-EM studies
Qun Liu (USA)
Structural mechanism for a transmembrane Ca2+ leak
Filip Van Petegem (Canada) Selected oral Communication
Crystallographic investigation of the calcium sensing apparatus of voltage-gated sodium and calcium channels: effect of arrhythmia-causing mutations.
Katrien Willegems (Belgium) Selected oral Communication
Ryanodine receptor in the open state with and without ryanodine
10:30 h Coffee break #3
11:00 h New tools for calcium imaging
Chair, Juan Llopis (Spain)
Masamitsu Iino (Japan)
Use of CEPIA indicators for the study of intraorganellar Ca2+ dynamics
Oliver Griesbeck (Germany)
All-optical genetic screening for synaptic vesicle recycling genes in C. elegans
María T. Alonso (Spain)
In vivo imaging of Ca2+ in the endoplasmic reticulum with GAP sensors
Ágota Apáti (Hungary) Selected oral Communication
Genetically engineered calcium indicators for visualization of calcium signals: from single cells to tissues.
Fabiana Perocchi (Germany) Selected oral Communication
From functional genomics to drug re-purposing: the mitochondrial uniporter case
David Castrillo (Spain) Sponsor brief presentation
New Imaging tools from Hamamatsu Photonics
13:00 h Lunch #3
14:00 h Poster Session #3
15:00 h ECS General Assembly
16:00 h Berridge Lecture
Prof. James W. Putney (USA) introduced by Martin D. Bootman (UK)
Signaling functions of store-operated Ca2+ channels
17:30 h Visit to a selected Ribera del Duero Vineyard
21:00 h Conference Banquet
09:00 h MicroRNA and calcium signaling
Chair, Catherine Leclerc (France)
Na Li (USA)
MicroRNA and calcium signaling in atrial fibrillation
Sebastian Albinsson (Sweden)
MicroRNA and calcium handling in cardiac diseases
Enikö Kallay (Austria)
MicroRNAs and the calcium-sensing receptor
Agne Tilunaite (UK) Selected oral Communication
Cellular calcium signalling in the presence of single cell variability and dynamic stimuli.
Mª Cristina López-Méndez (Mexico) Selected oral Communication
Ryanodine receptors of acidic Ca2+ stores generate a non-productive Ca2+ release in smooth muscle cells.
11:00 h Coffee break #4
11:30 h Calcium, stem cells and regeneration
Chair, Andrew Miller (Hong-Kong, China)
Jonathan Marchant (USA)
Calcium signaling and CNS regeneration in planaria
Catherine Leclerc (France)
Calcium signaling in glioblastoma stem cells
Yianbo Yue (Hong-Kong, China)
Role of CD38/cADPR/Ca2+ signaling in differentiation of mouse ES cells
Carles Rentero (Spain) Selected oral Communication
Annexin A6-mediated alanine uptake is necessary for liver regeneration in mice
Sachie Kanatani (Sweden) Selected oral Communication
Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii
13:30 h Awards ceremony and concluding remarks.
14:00 h Farewell´s cocktail at the venue´s garden.